Journal of the American Dental Association: Oral bisphosphonate use and the prevalence of osteonecrosis of the jaw
Essential Evidence Plus: Benefit of low-dose aspirin for type 2 diabetes is uncertain
MeReC: Lipid-modifying treatment
Canadian Medical Journal: Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis.

Annals of Internal Medicine: Alcohol Screening Scores and Medication Nonadherence
The Lancet: Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis
JAMA: Vitamins E and C and selenium are ineffective in preventing prostate cancer
Canadian Medical Association Journal: Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis.

US Pharmacist: SSRIs and Serotonin Syndrome
US Pharmacist: Postpartum Depression
Thorax: Varenicline similar in effectiveness to nicotine patch
American Academy of Dermatology: Position Statement on vitamin D.

Diabetes Care: Egg Consumption and Risk of Type 2 Diabetes in Men and Women
Archives of Internal Medicine: Comparison of Cardiovascular Outcomes in Elderly Patients With Diabetes Who Initiated Rosiglitazone vs Pioglitazone Therapy
Australian Prescriber: Hypnotic hazards: adverse effects of zolpidem and other z-drugs
Australian Prescriber: Lifestyle management of hypertension

MeReC Monthly: Anticholinergics in COPD — new data on cardiovascular safety
Internal Medicine Journal: Patterns of glycaemic control in Australian primary care (NEFRON 8)
Annals of Pharmacotherapy: Effects of Garlic on Blood Pressure in Patients With and Without Systolic Hypertension: A Meta-Analysis
New England Journal of Medicine: Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein (JUPITER trial).

Archives of Internal Medicine: Calcium supplements in middle-aged men – higher but not lower doses increase BMD
BMJ: Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis
Journal of Clinical Endocrinology & Metabolism: Vitamin D Insufficiency Linked to Increased Body Fat
JAMA: Ginkgo biloba for Prevention of Dementia.

JAMA: Low-Dose Aspirin for Primary Prevention of Atherosclerotic Events in Patients With Type 2 Diabetes
JAMA: Folic Acid and B Vitamins Ineffective for Cancer Prevention
US Pharmacist: Drug-Induced Hypertension
Medscape: Chondroitin and Glucosamine: Hype or Hope for Osteoarthritis?

Journal for Nurse Practitioners: Walking the Tightrope: Chronic Pain and Substance Abuse
Chest, Archives of Internal Medicine: Bisphosphonates May Increase Risk of Atrial Fibrillation
Archives of Internal Medicine: Metformin May Reduce Cardiovascular Risk in Type 2 Diabetes
British Medical Journal: Maternal caffeine intake during pregnancy and risk of fetal growth restriction.

The Journal of Family Practice: Vasomotor symptoms: Managing the transition from perimenopause to postmenopause
Current Clinical Practice: Initiating and intensifying therapy in type 2 diabetes: Managing the progressive nature of the disease
Journal of the American College of Cardiology: Relation of Beta-Blocker-Induced Heart Rate Lowering and Cardioprotection in Hypertension
Clinical Diabetes: Hypoglycemia.

Australian Prescriber: How to treat hypercholesterolaemia
Annals of Pharmacotherapy: Aspirin, Clopidogrel, and Warfarin: Is the Combination Appropriate and Effective or Inappropriate and Too Dangerous
Journal of the American Pharmacists Association: The Medication Assessment Program: Comprehensive Medication Assessments for Persons Taking Multiple Medications for Chronic Diseases
Archives of Neurology: Vitamin D Deficiency May Be More Common in Parkinson's Disease.

Due to a 'technical error', instead of publishing this week's Research Roundup on Monday we republished last week's. Here is this week's now  

Neurology: The diagnostic evaluation and treatment of trigeminal neuralgia (an evidence-based review)
Cochrane Database of Systematic Reviews: St John's wort for major depression
Journal of Rheumatology: Factors affecting persistence with weekly bisphosphonates
BMJ: The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease.

National Heart Foundation: Fish, fish oils, n-3 polyunsaturated fatty acids and cardiovascular health
European Heart Journal: Hormone therapy and risk of myocardial infarction: a national register study
ADRAC Bulletin: Fatal interactions and reactions with colchicine: beware CYP3A4 inhibitors
Medical Journal of Australia: Topical ophthalmic medications: what potential for systemic side effects and interactions with other medications?

American Family Physician: Recommendations Issued for Managing Mastitis in Mothers Breast-Feeding Their Infants
JAMA: Inhaled Anticholinergics and Risk of Major Adverse Cardiovascular Events in Patients With Chronic Obstructive Pulmonary Disease
Annnals of Internal Medicine: Risk for Death Associated with Medications for Recently Diagnosed Chronic Obstructive Pulmonary Disease
Journal of Family Practice: The role of incretin therapy for type 2 diabetes in family medicine.

BMJ: Adherence to Mediterranean diet and health status
Medical Journal of Australia: A 5- versus 3-day course of oral corticosteroids for children with asthma exacerbations who are not hospitalised: a randomised controlled trial
British Journal of Clinical Pharmacology: Red ginseng for treating erectile dysfunction: a systematic review
New England Journal of Medicine: Long-Term Follow-up after Tight Control of Blood Pressure in Type 2 Diabetes

The week’s special edition Research Roundup looks at the Lancet ‘paracetamol’ paper that’s causing all the fuss.

Many thanks to Debbie Rigby for working this up over the weekend for us, including commenting on the study's relevance to practice.

Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6–7 years: analysis from Phase Three of the ISAAC programme

Abstract

Exposure to paracetamol during intrauterine life, childhood, and adult life may increase the risk of developing asthma. We studied 6–7-year-old children from Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) programme to investigate the association between paracetamol consumption and asthma.

BMJ: Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial
New England Journal of Medicine: Analyses of Cancer Data from Three Ezetimibe Trials
Archives of Internal Medicine: Postmenopausal Hormone Use and Symptoms of Gastroesophageal Reflux
Arthritis Care and Research: Ibuprofen Use Increases Cardiovascular Risk but Not for All Older Patients

Urologic Nursing: Urinary Incontinence in the Childbearing Woman
Medscape: Is Penicillin Safe in a Patient Allergic to Cephalosporins?
Medical Journal of Australia: Contemporary management of type 2 diabetes: blood glucose-lowering therapies and glycaemic targets
Medical Journal of Australia: Migraine prophylaxis.

Pharmacy and Therapeutics: The Pharmacological management of migraine part 2: preventative therapy
Thorax: Patient adherence in COPD
JAMA: Nut, Corn, and Popcorn Consumption and the Incidence of Diverticular Disease
BMJ: Health related quality of life after combined hormone replacement therapy.

Canadian Medical Journal: Use of proton pump inhibitors and risk of osteoporosis related fractures
FDA: Combining Simvastatin with Amiodarone increases the risk for rhabdomyolysis
Archives of Internal Medicine: 25-Hydroxyvitamin D Levels and the Risk of Mortality in the General Population
Family Practice: In-practice management versus quitline referral for enhancing smoking cessation in general practice: a cluster randomized trial.